Medication-Induced Repigmentation of Gray Hair: A Systematic Review

The document reviewed 27 studies on medication-induced repigmentation of gray hair, with 6 studies focusing primarily on treatments like psoralen and vitamin supplementation, and 21 reports where repigmentation was an incidental finding. Medications associated with gray hair repigmentation included anti-inflammatory drugs, melanogenesis stimulators, vitamins, and other drugs with various mechanisms. The findings suggest that certain medications can induce repigmentation by either inhibiting inflammation or stimulating melanogenesis, and there is some low-quality evidence that vitamin B complex supplementation may help darken gray hair. Although these medications are not approved for treating gray hair, they provide insight into potential targets for future hair repigmentation treatments.