The Hair Loss Encyclopedia

Segmented Heterochromia in Black Scalp Hair Associated With Iron-Deficiency Anemia

April 1989 in “ Archives of Dermatology ”

Syozo Sato

TLDR Iron deficiency can cause hair color changes, which can be reversed with iron supplements.

A 15-year-old girl exhibited segmented heterochromia in her black scalp hair, characterized by alternating dark and light bands, which was associated with iron-deficiency anemia. Clinical and laboratory investigations suggested that low serum iron levels were crucial in reducing eumelanogenesis and possibly affecting melanin transfer. The condition resolved completely following iron supplementation, which led to increased eumelanogenesis in the hair. This case indicated that iron played a significant role in the process of melanogenesis within follicular melanocytes.

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