Comparative Transcriptomic Analysis of Human Mesenchymal Stem Cells Derived from Dental Pulp and Adipose Tissues

    May 2019 in “ Journal of Stem Cells & Regenerative Medicine ”
    Atsushi Terunuma, Keisuke Ashiba, Tsubasa Takane, Yosuke Sakaguchi, Hiroshi Takahashi
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    TLDR Dental pulp stem cells are better for tissue repair, while fat tissue stem cells may be more suited for wound healing and hair growth.
    In 2019, a comparative analysis was conducted on the transcriptomes of human mesenchymal stem cells (hMSCs) derived from dental pulp and adipose tissues. The study involved 7 samples of dental pulp-derived hMSCs and 6 samples of adipose tissue-derived hMSCs. The results indicated that dental pulp-derived hMSCs had a higher expression of genes related to cell proliferation, differentiation, and mineralization, suggesting their potential use in tissue engineering and regenerative medicine. Conversely, adipose tissue-derived hMSCs showed a higher expression of genes associated with cell adhesion, extracellular matrix organization, angiogenesis, and hair growth, indicating their potential use in wound healing, anti-inflammatory applications, and conditions requiring increased blood supply and hair loss treatment. The study concluded that the source of MSCs could influence their gene expression and potential therapeutic applications.
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