Hair Graying Regulators Beyond Hair Follicle

    February 2022 in “ Frontiers in physiology
    Jing Chen, Yixin Zheng, Chen Hu, Xuexiao Jin, Xiaoping Chen, Ying Xiao, Chaochen Wang
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    TLDR Hair graying is influenced by factors like nerves, fat cells, and immune cells, not just hair follicles.
    Hair graying results from the depletion and dysfunction of melanocyte stem cells (MeSCs) in the hair follicle bulge, but the exact causes are not fully understood. Recent studies indicate that external factors such as nerves, adipocytes, and immune cells also significantly influence MeSC regulation. This review explores these external influences on MeSCs and discusses their roles in hair graying, suggesting potential new treatments for this condition.
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