Adiponectin Negatively Regulates Pigmentation, Wnt/β-Catenin and HGF/c-Met Signaling Within Human Scalp Hair Follicles Ex Vivo

December 2021 in “ Archives of Dermatological Research ”

Carina Nicu, Jennifer Jackson, Asim Shahmalak, Jenny Pople, David M. Ansell, Ralf Paus

adiponectin pigmentation Wnt/β-catenin signaling HGF/c-Met signaling hair follicles hair pigmentation hair growth

TLDR Adiponectin reduces hair pigmentation and affects hair growth signals.

The study investigated the role of adiponectin in human scalp hair follicles ex vivo, focusing on its impact on pigmentation and signaling pathways. It was found that adiponectin negatively regulated pigmentation and inhibited the Wnt/β-catenin and HGF/c-Met signaling pathways within the hair follicles. These findings suggested that adiponectin played a role in modulating hair follicle biology, potentially influencing hair pigmentation and growth processes. The study provided insights into the complex interactions between adiponectin and hair follicle signaling, contributing to the understanding of hair biology and potential therapeutic targets for hair-related conditions.

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