Association of Epidemiological and Biochemical Factors with Premature Graying of Hair: A Case-Control Study

The study identified several factors associated with premature graying of hair (PHG) in 120 patients under 25 years old and an equal number of controls. Significant associations included family history, atopic diathesis, sedentary lifestyle, smoking, and higher perceived stress. Biochemically, lower levels of serum calcium, ferritin, Vitamin B12, HDL, and higher LDL were linked to PHG. Hair oiling appeared protective. The study concluded that genetic predisposition and nutritional deficiencies played crucial roles in PHG, but further research with larger sample sizes is needed to confirm these findings and develop preventive and therapeutic strategies.