Raman Investigation of In Vivo Radiation Exposure on Melanin in Murine Hair

March 2025 in “ PNAS Nexus ”

Monika Poonia, Spencer A. Witte, Martin J. Woodward, Prasant Yadav, Sapna Puri, Ramasamy Santhanam, Naduparambil K. Jacob, Zachary D. Schultz

Raman spectroscopy melanin gamma radiation biomarkers radiation exposure C57BL/6 mice 785-nm excitation wavelength radiation biodosimetry

Studysummary In this study, researchers used Raman spectroscopy to identify melanin-specific features in mouse hair as potential biomarkers for gamma-radiation exposure, achieving a sensitivity of 88% and specificity of 83%, with classification accuracy declining over time beyond 7 days post-irradiation.

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research Raman Investigation of In Vivo Radiation Exposure on Melanin in Murine Hair

2 citations , March 2025 in “PNAS Nexus”

In this study, researchers used Raman spectroscopy to identify melanin-specific features in mouse hair as potential biomarkers for gamma-radiation exposure, achieving a sensitivity of 88% and specificity of 83%, with classification accuracy declining over time beyond 7 days post-irradiation.

Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

research Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

January 2024 in “GeroScience”

This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.

research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

21 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

This review covers the structure, development, cycle, and molecular regulation of hair follicles but does not report new results, aiming to offer insights for addressing hair follicle-related diseases.

research Exposure to Gamma-Rays at the Telogen Phase of the Hair Cycle Inhibits Hair Follicle Regeneration at the Anagen Phase in Mice

6 citations , November 2013 in “International Journal of Radiation Biology”

In this study, γ-ray irradiation of mice reduced hair follicle density and pigmentation, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.