Raman Investigation of In Vivo Radiation Exposure on Melanin in Murine Hair

    March 2025 in “ PNAS Nexus ”
    Monika Poonia, Spencer A. Witte, Martin J. Woodward … Zachary D. Schultz
    Studysummary In this study, researchers used Raman spectroscopy to identify melanin-specific features in mouse hair as potential biomarkers for gamma-radiation exposure, achieving a sensitivity of 88% and specificity of 83%, with classification accuracy declining over time beyond 7 days post-irradiation.
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    Research cited in this study 4

    1. Raman Investigation of In Vivo Radiation Exposure on Melanin in Murine Hair PNAS Nexus · 2025
    2. Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence GeroScience · 2024
    3. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    4. Exposure to Gamma-Rays at the Telogen Phase of the Hair Cycle Inhibits Hair Follicle Regeneration at the Anagen Phase in Mice International Journal of Radiation Biology · 2013