Establishing a Robust Preclinical Model to Investigate Early and Late Radiation-Induced Skin Reactions

The study established a murine model to investigate early and late radiation-induced skin reactions (RISRs) using fractionated radiation doses of 30 Gy and 50 Gy on male Swiss albino mice. The model showed dose-dependent skin damage, with the 50 Gy group experiencing more severe reactions, including dermal inflammation, ulceration, and reduced hair follicle density. Late effects included dermal indentations and persistent hair follicle loss. Despite a small sample size of 20 mice, the model effectively replicates clinical features of RISRs, providing a basis for future research into radiation therapy effects and potential interventions.