Apoptosis in Growing Hair Follicles Following Gamma-Irradiation and Application for the Evaluation of Radioprotective Agents

    June 2003 in “ PubMed ”
    Kim Sh, Ki Wook Kim, Hyo Jong Lee, Hyuncheol Oh, Ryu Sy, Lee Ys, Tae Hyeon Kim, Jo Sk
    TLDR Radiation increases cell death in hair follicles, but certain treatments can protect against this effect.
    In a study conducted 20 years ago, researchers examined the effects of gamma-irradiation on hair follicles in mice and the potential of radioprotective agents. The study found that gamma-irradiation led to a dose-related increase in apoptotic (cell death) cells in the hair follicles. The highest frequency of apoptotic cells was observed 12 hours after exposure to 100 cGy of gamma-rays. However, pretreatment with diethyldithiocarbamate (DDC) 30 minutes before irradiation or green tea 12 and 36 hours before irradiation significantly reduced the frequency of radiation-induced apoptosis in hair follicles. The researchers concluded that this model could be useful in detecting radiation response and evaluating radioprotective agents.
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