Single Dose Gamma Irradiation Induced Angiogenesis in Rat Skin Hair Follicles

October 2020 in “ Internatuinal Journal of Radiation Research ”

Gh. K. El Khalafawy, A.A. Elkady, Safinaz Sayed, A. F. El Bedewi

TLDR Gamma irradiation can stimulate hair growth by promoting new blood vessel formation.

The study investigated the effects of a single dose of gamma irradiation (10Gy) on hair follicles in 50 rats, divided into control and irradiated groups. Results showed that gamma irradiation led to epidermal thinning, dermal inflammation, and increased formation of new blood vessels around hair follicles, as indicated by CD31 staining. Additionally, there was a significant increase in pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and malondialdehyde (MDA) levels, while antioxidant enzymes (CAT and SOD) decreased in the irradiated group compared to controls. The study concluded that gamma irradiation could have beneficial and stimulatory effects on hair growth.

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