In Vivo Quantification of the Effects of Radiation and Presence of Hair Follicle Pores on the Proliferation of Fibroblasts in an Acellular Human Dermis in a Dorsal Skinfold Chamber: Relevance for Tissue Reconstruction Following Neoadjuvant Therapy

May 2015 in “ PloS one ”

Mario Vitacolonna, Djeda Belharazem, Patrick Maier, Peter Hohenberger, Eric Dominic Roessner

radiation hair follicle pores fibroblast proliferation acellular human dermis dorsal skinfold chamber tissue reconstruction neoadjuvant therapy

TLDR Hair follicle pores help cell survival and growth, even after radiation.

The study examined the impact of radiation and hair follicle pores on fibroblast proliferation in an acellular human dermis using a rat model. It involved 24 rats divided into irradiated and non-irradiated groups, with further subdivisions based on the presence of hair follicle pores. Results indicated that radiation reduced cell proliferation, but the presence of hair follicle pores improved cell survival and proliferation even in irradiated conditions. This suggested that hair follicle pores could enhance cell viability and proliferation, which is crucial for tissue reconstruction post-neoadjuvant therapy.

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