Premature Graying of Hair: Risk Factors, Co-Morbid Conditions, Pharmacotherapy and Reversal—A Systematic Review and Meta-Analysis

    July 2020 in “ Dermatologic therapy
    Saniya Mahendiratta, Phulen Sarma, Hardeep Kaur, Sukhdeep Kaur, Harpinder Kaur, Seema Bansal, Davinder Prasad, Manisha Prajapat, Sujata Upadhay, Subodh Kumar, Harish Kumar, Rahul Singh, Ashutosh Singh, Abhishek Mishra, Ajay Prakash, Bikash Medhi
    TLDR Premature graying of hair is linked to various health issues and can sometimes be reversed by treating underlying conditions.
    The systematic review and meta-analysis from July 28, 2020, examined the risk factors, co-morbid conditions, pharmacotherapy, and potential for reversal of premature graying of hair. The study identified several risk factors including genetic predisposition, oxidative stress, and nutritional deficiencies. It also found associations between premature graying and conditions such as autoimmune disorders and cardiovascular diseases. Pharmacological interventions were explored, but evidence for effective treatments was limited. The review concluded that while some factors contributing to premature graying were understood, more research was needed to develop effective therapies for reversing the condition.
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