Serum Micronutrient Levels in Premature Canities: A Systematic Review and Meta-Analysis

    December 2021 in “ Dermatology research ”
    Nur Camelia, Diah Adriani Malik, Puguh Riyanto, Asih Budiastuti, Retno Indar Widayati, Mustakiza Muslimin, H Hardian
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    TLDR Low levels of vitamin B12, ferritin, and calcium are linked to premature graying of hair.
    The systematic review and meta-analysis examined serum levels of vitamin B12, iron, ferritin, copper, calcium, and zinc in individuals with premature canities (n = 1791). The meta-analysis revealed significantly lower serum levels of vitamin B12, ferritin, and calcium in those with premature canities, while differences in iron, copper, and zinc levels were not significant. Qualitative analysis indicated that deficiencies in these micronutrients can impact hair melanogenesis, contributing to premature graying.
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