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Glossary Melanogenesis

process of producing melanin in skin and hair cells

Melanogenesis is the process by which the skin and hair produce melanin, the pigment responsible for their color. This process occurs in specialized cells called melanocytes and involves a series of biochemical reactions, primarily catalyzed by the enzyme tyrosinase. Melanogenesis is influenced by genetic factors, UV exposure, and hormonal changes, and plays a crucial role in protecting the skin from UV radiation.

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Research

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research ABSENCE OF H2O2 BREAKDOWN IN HUMAN HAIR MEDULLA IMPLICATIONS IN FOLLICULAR MELANOGENESIS

1 citations , September 2018 in “International journal of research - granthaalayah”

This paper introduces a new understanding that the human hair follicle medulla lacks metabolic activity for H2O2 breakdown, indicating that H2O2 decomposition occurs primarily in the cortical areas.

research Influence of prostaglandin F_2α and its analogues on hair regrowth and follicular melanogenesis in a murine model

103 citations , April 2005 in “Experimental dermatology”

This study found that PGF2alpha analogues and PGE2 stimulated hair follicle activity in mice, with PGF2alpha analogues also linked to potential side effects like poliosis when used as eye treatments.

research Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

29 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, silencing P-cadherin in human scalp hair follicles reduced melanogenesis and associated protein expression, suggesting P-cadherin is crucial for normal hair pigmentation via GSK3β-mediated Wnt signaling.

research Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains

6 citations , October 2018 in “PLoS ONE”

This study found that chronic stress may inhibit hair follicle growth and melanogenesis in mice through modulation of the central HPA axis, with C57BL/6 mice appearing most sensitive to these effects.

research Hair Follicle Melanogenesis Reflected in Hair Pigmentation as a Developmental Factor in Alopecia Areata

3 citations , January 2021 in “Skin appendage disorders”

This study concluded that hair pigmentation, as measured by eumelanin-to-pheomelanin ratio, is not a risk factor for developing alopecia areata when compared to androgenetic alopecia patients.

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Community Join

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community Making your own RT1640 in China

4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

community Fin/Dut + Min or Shave it off and get used to being bald, Hair System is a non-option.

16 upvotes 5 days ago

Hair systems can be effective but may cause anxiety and maintenance issues, while some prefer medications like finasteride and minoxidil despite potential side effects. Ultimately, personal confidence and character are more important than hair appearance.

community Why Dr. Arif Abid is the Best for Hair Loss

in Hair Loss Experts 6 upvotes 1 week ago

Dr. Arif Abid is highly recommended for hair loss treatment. Minoxidil, finasteride, and RU58841 are mentioned as effective treatments.

community Everyone needs to use their GPT-6 Astra credits on hair loss immediately

90 upvotes 1 week ago

Hair loss treatments like finasteride, minoxidil, and dutasteride are discussed, with some users expressing skepticism about finding a permanent cure. Current treatments are considered effective but not a permanent solution, and there's a call for advanced AI to focus on solving male pattern baldness.

community Hair Transplant 1 year later - 3206 Grafts Bogata Hairlines

188 upvotes 1 week ago

The user is mostly satisfied with their hair transplant of 3206 grafts from Bogota Hairlines in Colombia, noting the right side feels stringy. They have been using oral minoxidil and finasteride, and recently added topical GHK-cu to enhance growth.

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Learn

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learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn Stem Cell Factor

learn Hair Fibers

cosmetic product that temporarily makes hair appear thicker

Do hair fibers really make thinning hair look fuller, or is it just an illusion? Hair fibers create an optical illusion of fullness but do not actually thicken hair.
How do you apply hair fibers correctly so they stay in place all day? Apply hair fibers to clean, dry hair and use a setting spray for better hold.
Can hair fibers be used along with medical treatments like minoxidil or finasteride? Yes, hair fibers can be used with minoxidil or finasteride without any chemical interaction.
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learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

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Clinics

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas