Role of Annexin A2 Isoform 2 on the Aggregative Growth of Dermal Papillae Cells

The study investigated the role of Annexin A2 isoform 2 in the growth of dermal papillae cells (DPC), which are crucial for hair growth. Using RT-PCR and Western blot, it was found that Annexin A2 isoform 2 was up-regulated in early passage DPC (passage 3) compared to later passage DPC (passage 10). Suppressing Annexin A2 isoform 2 with siRNA in passage 3 DPC reduced their proliferation, while over-expressing it in passage 10 DPC increased their proliferation. These findings suggested that Annexin A2 isoform 2 played a role in regulating DPC proliferation and might be linked to the hair follicle growth cycle.