TLDR HSPC016 gene is important for hair growth.
The study identified differentially expressed genes in dermal papilla cells (DPCs) with aggregative behavior, which are crucial for hair follicle cycling. Using suppression subtractive hybridization, researchers isolated mRNA from DPCs with and without aggregative behavior, leading to the identification of five differentially expressed genes, including capping protein, paladin, and vascular endothelial growth factor. Notably, the gene HSPC016, originally cloned from CD34+ hematopoietic stem/progenitor cells, was found to be differentially expressed in DPCs with aggregative behavior. The full-length cDNA of HSPC016 was 366 bp, and it was suggested to have a role in transcriptional regulation.
66 citations
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August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
57 citations
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November 1998 in “Wound Repair and Regeneration” Hair papilla cells can create and regenerate hair bulbs under the right conditions.
90 citations
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October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.
106 citations
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April 1986 in “British Journal of Dermatology” Dermal papilla cells from human hair follicles form unique structures and don't live as long as other skin cells in lab conditions.
January 2022 in “Journal of St. Marianna University” Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
15 citations
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April 2014 in “Experimental Dermatology” Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
321 citations
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December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
32 citations
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August 2006 in “Archives of Dermatological Research” Dermal papilla cells can help regrow hair follicles.
January 2003 in “Chinese Journal of Reparative and Reconstructive Surgery” Dermal papilla cells can help form hair follicles and produce hair.
66 citations
,
August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
57 citations
,
November 1998 in “Wound Repair and Regeneration” Hair papilla cells can create and regenerate hair bulbs under the right conditions.
