TLDR Rat dermal papilla cells have unique genes crucial for hair growth.
The study analyzed gene expression in rat dermal papilla (DEPA) cells, which are crucial for hair growth, by sequencing 5130 clones from a DEPA cDNA library. Results showed that 50% of the sequences had high similarity to known proteins, with 21% related to cell structure/motility and many encoding extracellular matrix proteins. Growth factor molecules were also prevalent. The remaining 50.7% of sequences had low similarity scores, indicating the presence of many novel molecules, including a new member of the CTGF family, the rat homologue of Elm1. This highlighted the molecular differences between DEPA cells and fibroblasts, emphasizing DEPA cells' unique role in hair follicle induction.
Cited in this study
4 / 4 results
231 citations
,
October 1999 in “Journal of Clinical Investigation” Activating the Sonic hedgehog gene in mice can start the hair growth phase.
27 citations
,
September 1999 in “Journal of Investigative Dermatology” Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.
67 citations
,
February 1994 in “Developmental dynamics” Specific proteins and molecules play key roles in the development of human hair follicles.
45 citations
,
December 1991 in “Annals of the New York Academy of Sciences” ECM molecules are crucial for hair growth and development.
January 2022 in “Journal of St. Marianna University” Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
15 citations
,
May 2014 in “Experimental Dermatology” Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
321 citations
,
January 2010 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
January 2003 in “Chinese Journal of Reparative and Reconstructive Surgery” Dermal papilla cells can help form hair follicles and produce hair.
66 citations
,
August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
57 citations
,
November 1998 in “Wound Repair and Regeneration” Hair papilla cells can create and regenerate hair bulbs under the right conditions.
