Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs

October 2000 in “ Genomics ”

Matthew A. Sleeman, J. Greg Murison, Lorna Strachan, Krishnanand D. Kumble, M. Glenn, Annette McGrath, A.W. Grierson, Ilkka Havukkala, Paul Tan, James D. Watson

dermal papilla cells hair growth cDNA library extracellular matrix proteins growth factor molecules CTGF family Elm1 hair follicle induction DEPA cells growth factors

TLDR Rat dermal papilla cells have unique genes crucial for hair growth.

The study analyzed gene expression in rat dermal papilla (DEPA) cells, which are crucial for hair growth, by sequencing 5130 clones from a DEPA cDNA library. Results showed that 50% of the sequences had high similarity to known proteins, with 21% related to cell structure/motility and many encoding extracellular matrix proteins. Growth factor molecules were also prevalent. The remaining 50.7% of sequences had low similarity scores, indicating the presence of many novel molecules, including a new member of the CTGF family, the rat homologue of Elm1. This highlighted the molecular differences between DEPA cells and fibroblasts, emphasizing DEPA cells' unique role in hair follicle induction.

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Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs

Research cited in this study

research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog

research The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen

research Local Injection of Hepatocyte Growth Factor/Scatter Factor Alters Cyclic Growth of Murine Hair Follicles

research Message of Nexin 1, a Serine Protease Inhibitor, Accumulates in the Follicular Papilla During Anagen of the Hair Cycle

research Transfection of Rat Dermal Papilla Cells with a Gene Encoding a Temperature-Sensitive Polyomavirus Large T Antigen Generates Cell Lines Retaining a Differentiated Phenotype

research Dynamic Expression Patterns of Tenascin, Proteoglycans, and Cell Adhesion Molecules During Human Hair Follicle Morphogenesis

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

research Distribution of Extracellular Matrix Molecules in Human Hair Follicles

research Expression of Basement Membrane Proteins and Interstitial Collagens in Dermal Papillae of Human Hair Follicles

research Rat Hair Follicle Dermal Papillae Have an Extracellular Matrix Containing Basement Membrane Components

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