Exosomal miR-222-3p Derived from Dermal Papilla Cells Inhibits Melanogenesis in Melanocytes by Targeting SOX10 in Rabbits

August 2024 in “ Animal Bioscience ”

Yang Chen, Tingting Lu, Yingying Dai, Yu Xue, Bohao Zhao, Xinsheng Wu

exosomal miR-222-3p dermal papilla cells melanogenesis melanocytes SOX10 apoptosis melanin synthesis

Studysummary This study found that in Rex rabbits, exosomal miR-222-3p from dermal papilla cells suppresses melanogenesis in melanocytes by targeting the SOX10 gene, highlighting a novel mechanism by which exosomes influence melanin production.

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The study investigates the role of exosomal miR-222-3p derived from dermal papilla cells in inhibiting melanogenesis in melanocytes by targeting the SOX10 gene in rabbits. The findings suggest that miR-222-3p can downregulate SOX10, a critical transcription factor involved in melanocyte development and function, thereby reducing melanin production. This research highlights a potential mechanism for controlling pigmentation, which could have implications for treating pigmentation disorders.

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