MiR-200a-3p in Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuates UVB-Induced Skin Inflammatory Response and Oxidative Stress via Keap1-Nrf2 Pathway
January 2025
in “
Stem Cells International
”
human umbilical cord mesenchymal stem cell-derived exosomes UVB-induced skin damage reactive oxygen species proinflammatory cytokines Keap1 Nrf2 antioxidant genes miR-200a-3p NF-κB pathway HuMSC-Exos UVB skin damage ROS inflammatory cytokines Keap1-Nrf2 pathway antioxidants microRNA-200a-3p NF-kappa B pathway
TLDR Exosomes from stem cells can reduce UV-induced skin damage by lowering inflammation and oxidative stress.
The study investigates the protective effects of human umbilical cord mesenchymal stem cell-derived exosomes (HuMSC-Exos) on UVB-induced skin damage in HaCaTs and C57BL/6 mice. HuMSC-Exos were found to significantly reduce reactive oxygen species levels, suppress proinflammatory cytokines, and improve cell migration. The exosomes inhibited Keap1, enhanced Nrf2 expression and its nuclear translocation, and upregulated antioxidant genes, with miR-200a-3p playing a key role by targeting Keap1. Additionally, HuMSC-Exos may attenuate inflammatory responses via the NF-κB pathway. The findings suggest that HuMSC-Exos have therapeutic potential in reducing UV-induced skin damage by modulating oxidative stress and inflammation.
