Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway

    August 2025 in “ Stem Cell Research & Therapy
    Ai-Qing Yu, Yujun Zhang, Shuping Zhong, Zhizhen Yang, Mingming Xie
    Image of study
    TLDR Exosomes from stem cells can help regrow hair better than minoxidil.
    The study explores the potential of human umbilical cord mesenchymal stem cell-derived exosomes (MSC-Exo) in promoting hair follicle regeneration in androgenetic alopecia (AGA) by activating the Wnt/β-catenin signaling pathway. Using male C57BL/6 mice, the research demonstrates that MSC-Exo can enhance hair regrowth, improve follicular architecture, and outperform 5% minoxidil, a common hair loss treatment. The exosomes, enriched with microRNAs like miR-21-5p and let-7b-5p, target genes crucial for hair follicle function, leading to increased anagen phase duration, follicular enlargement, and improved dermal papilla cell proliferation and differentiation. These findings suggest MSC-Exo as a promising therapeutic strategy for AGA, though further studies are needed to confirm these effects in humans.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

    Similar Research

    5 / 1000+ results