TLDR Exosomes from stem cells can help regrow hair better than minoxidil.
The study explores the potential of human umbilical cord mesenchymal stem cell-derived exosomes (MSC-Exo) in promoting hair follicle regeneration in androgenetic alopecia (AGA) by activating the Wnt/β-catenin signaling pathway. Using male C57BL/6 mice, the research demonstrates that MSC-Exo can enhance hair regrowth, improve follicular architecture, and outperform 5% minoxidil, a common hair loss treatment. The exosomes, enriched with microRNAs like miR-21-5p and let-7b-5p, target genes crucial for hair follicle function, leading to increased anagen phase duration, follicular enlargement, and improved dermal papilla cell proliferation and differentiation. These findings suggest MSC-Exo as a promising therapeutic strategy for AGA, though further studies are needed to confirm these effects in humans.
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January 2021 in “Biomedicine & Pharmacotherapy” DHT stops hair regrowth in mice, similar to human hair loss.
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October 2016 in “Molecular and Cellular Endocrinology” Androgens prevent hair growth by changing Wnt signals in cells.
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December 2015 in “BMC Complementary and Alternative Medicine” A new plant extract from Avicennia marina could potentially be used to treat common hair loss.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
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March 1998 in “British Journal of Dermatology” Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.
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July 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.
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December 2023 in “Regenerative therapy” miRNA-based therapies show promise for treating skin diseases, including hair loss, in animals.
June 2024 in “Regenerative Therapy” Exosomes from stem cells may help rejuvenate skin and regrow hair, but more research is needed.