Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition
September 2023
in “
Stem cell research & therapy
”
Studysummary In this study, umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles were found to improve wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.
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The study demonstrates that umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles (UCMSC-derived ApoEVs) significantly improve cutaneous wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis. This improvement is achieved through the reduction of oxidative stress and the downregulation of key pyroptosis-related proteins such as NLRP3, caspase-1, and gasdermin D. The findings suggest that UCMSC-derived ApoEVs could be a promising therapeutic approach for enhancing wound healing in diabetic patients by modulating inflammatory responses and oxidative stress.
