Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition

    September 2023 in “ Stem cell research & therapy ”
    Yiming Wang, Jiacheng Lin, Ling Xiao, Zhen Ma, Bei Li, Yuanyuan Shi, Wuyang Zhang, Yuan Li, Hongzhi Zhou, Kaijin Hu, Yang Xue, Yan Jin
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    TLDR Special particles from umbilical cord stem cells help heal skin wounds in diabetic mice by preventing certain immune cell death.
    The study demonstrates that umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles (UCMSC-derived ApoEVs) significantly improve cutaneous wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis. This improvement is achieved through the reduction of oxidative stress and the downregulation of key pyroptosis-related proteins such as NLRP3, caspase-1, and gasdermin D. The findings suggest that UCMSC-derived ApoEVs could be a promising therapeutic approach for enhancing wound healing in diabetic patients by modulating inflammatory responses and oxidative stress.
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