Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition

    September 2023 in “ Stem cell research & therapy ”
    Yiming Wang, Jiacheng Lin, Ling Xiao, Zhen Ma, Bei Li, Yuanyuan Shi, Wuyang Zhang, Yuan Li, Hongzhi Zhou, Kaijin Hu, Yang Xue, Yan Jin
    TLDR Special particles from umbilical cord stem cells help heal skin wounds in diabetic mice by preventing certain immune cell death.
    The study demonstrates that umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles (UCMSC-derived ApoEVs) significantly improve cutaneous wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis. This improvement is achieved through the reduction of oxidative stress and the downregulation of key pyroptosis-related proteins such as NLRP3, caspase-1, and gasdermin D. The findings suggest that UCMSC-derived ApoEVs could be a promising therapeutic approach for enhancing wound healing in diabetic patients by modulating inflammatory responses and oxidative stress.
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