ROS-Scavenging Microneedles Loaded with Portulaca Oleracea L.-Derived Exosomes for Atopic Dermatitis Therapy

October 2025 in “ Nano Research ”

Bo Zhao, Xinchi Jiang, Wanshu Li, Lian Zhang, Yihua Xu, Weitong Hu, Tianyuan Zhang, Ninggang Chen, Jianqing Gao, Hangjuan Lin

atopic dermatitis microneedle patch Portulaca oleracea exosome-like nanoparticles 4-amino-TEMPO hyaluronic acid oxidative stress Th1/Th2 immune balance AD MN patch PELNs HA-TEMPO

Studysummary In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.

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