ROS-Scavenging Microneedles Loaded with Portulaca Oleracea L.-Derived Exosomes for Atopic Dermatitis Therapy

October 2025 in “ Nano Research ”

Bo Zhao, Xinchi Jiang, Wanshu Li, Lian Zhang, Yihua Xu, Weitong Hu, Tianyuan Zhang, Ninggang Chen, Jianqing Gao, Hangjuan Lin

atopic dermatitis microneedle patch Portulaca oleracea exosome-like nanoparticles 4-amino-TEMPO hyaluronic acid oxidative stress Th1/Th2 immune balance AD MN patch PELNs HA-TEMPO

TLDR A new microneedle patch effectively treats atopic dermatitis by reducing skin stress and restoring immune balance.

The study addresses the challenge of treating atopic dermatitis (AD) by developing a dissolvable microneedle (MN) patch that incorporates Portulaca oleracea L.-derived exosome-like nanoparticles (PELNs) and 4-amino-TEMPO conjugated with hyaluronic acid (HA-TEMPO). This combination aims to overcome the limited antioxidant activity and poor skin penetration of PELNs. The HA-TEMPO@PELN-MN system demonstrated effective reduction of cutaneous oxidative stress and suppression of pathological skin crusting in vivo, while also restoring Th1/Th2 immune balance. The MN patch offers a promising, biocompatible, and controlled strategy for AD therapy, with rapid drug release and efficient delivery.

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ROS-Scavenging Microneedles Loaded with Portulaca Oleracea L.-Derived Exosomes for Atopic Dermatitis Therapy

Research cited in this study

research A Review on Ethnopharmacology, Phytochemistry, Pharmacology and Potential Uses of Portulaca Oleracea L.

research Protac Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration

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research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

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