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GlossaryTyrosinase-Related Protein 2 (TRP-2)

enzyme crucial for melanin production in hair and skin

Tyrosinase-Related Protein 2 (TRP-2), also known as Dopachrome Tautomerase (DCT), is an enzyme involved in the production of melanin, the pigment responsible for hair, skin, and eye color. It plays a crucial role in the melanin biosynthesis pathway by converting dopachrome into dihydroxyindole-2-carboxylic acid (DHICA), which helps determine the type and amount of melanin produced. This protein is significant in studies related to pigmentation disorders and melanoma.

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research N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) Targets TRP-2 and Inhibits Melanogenesis and Melanoma Growth

15 citations, April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

A3B5 can reduce skin pigmentation and slow melanoma growth.

research Symposium Proceedings of the 4th Intercontinental Meeting of Hair Research Societies: The World of Hair 2004

November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2004 hair research meeting presented new findings on hair cell differentiation, genetic factors in hair loss, hair pigmentation, and potential targeted therapies.

research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

12 citations, September 2018 in “International Journal of Cosmetic Science”

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress

67 citations, August 2013 in “International Journal of Cosmetic Science”

Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.

research Exploring the Potential Effect and Mechanisms of Protocatechuic Acid on Human Hair Follicle Melanocytes

3 citations, May 2020 in “Acta pharmaceutica”

Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.

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