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GlossaryTyrosinase-Related Protein 2 (TRP-2)

enzyme crucial for melanin production in hair and skin

Tyrosinase-Related Protein 2 (TRP-2), also known as Dopachrome Tautomerase (DCT), is an enzyme involved in the production of melanin, the pigment responsible for hair, skin, and eye color. It plays a crucial role in the melanin biosynthesis pathway by converting dopachrome into dihydroxyindole-2-carboxylic acid (DHICA), which helps determine the type and amount of melanin produced. This protein is significant in studies related to pigmentation disorders and melanoma.

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research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress

67 citations , August 2013 in “International Journal of Cosmetic Science”

Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.

research Betamethasone Activates Cultured Amelanotic Melanocytes Derived From Outer Root Sheath of Human Hair Follicle

January 2008 in “Linchuang pifuke zazhi”

Betamethasone activates and increases the growth of certain skin cells from hair follicles.

research Exploring the Potential Effect and Mechanisms of Protocatechuic Acid on Human Hair Follicle Melanocytes

3 citations , May 2020 in “Acta pharmaceutica”

Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.

research Symposium Proceedings of the 4th Intercontinental Meeting of Hair Research Societies: The World of Hair 2004

November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2004 hair research meeting presented new findings on hair cell differentiation, genetic factors in hair loss, hair pigmentation, and potential targeted therapies.

research Life of the B10 Mouse: A View from the Hair Follicles and Tissue Stem Cells

September 2023 in “Cells tissues organs”

Mice skin matures by day 200, leading to aging signs like curved hair follicles and white hairs due to changes in skin stem cells.

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