Melanogenesis-Promoting Effect of Cirsium Japonicum Flower Extract In Vitro and Ex Vivo
October 2021
in “
International Journal of Cosmetic Science
”
Cirsium japonicum flower extract melanogenesis human melanocytes 3D skin model ex vivo human hair follicles melanin tyrosinase activity eumelanin pheomelanin HPLC cAMP signaling pathway phosphorylated CRE-binding protein pCREB microphthalmia-associated transcription factor MITF follicular depigmentation vitiligo CFE melanin synthesis CREB hair follicles tyrosinase cAMP
Studysummary This study found that C. japonicum flower extract significantly increased melanin content and cellular activity in human melanocytes and may improve follicular depigmentation and vitiligo through cAMP signaling.
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The study investigated the melanogenesis-promoting effects of Cirsium japonicum flower extract (CFE) in vitro and ex vivo. CFE significantly increased melanin content and tyrosinase activity in lightly and moderately pigmented human melanocytes. It also elevated markers of eumelanin and pheomelanin, increased intracellular cAMP, and up-regulated proteins TYR and MITF. Additionally, CFE enhanced melanin content in a 3D skin model and ex vivo human hair follicles. These findings suggest that CFE can stimulate melanin synthesis through cAMP signaling, potentially improving conditions like follicular depigmentation and vitiligo.
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