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    Glossary 3D Skin Models

    laboratory-engineered tissues that mimic human skin structure

    3D Skin Models, also known as Three-Dimensional Skin Constructs or 3D Skin Equivalents, are laboratory-engineered tissues that mimic the structure and function of human skin. These models are created using layers of different cell types, such as keratinocytes and fibroblasts, to replicate the epidermis and dermis. They are used in research and testing to study skin biology, disease, and the effects of cosmetics or pharmaceuticals, providing a more accurate alternative to traditional 2D cell cultures and reducing the need for animal testing.

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    1. Post-Treatment of Micro-Needling with a Dexpanthenol-Containing Ointment Accelerates Epidermal Wound Healing in Human 3D Skin Models Clinical Cosmetic and Investigational Dermatology · 2023 · 2 citations
    2. 1344 Novel human 3D skin model for skin aging research Journal of Investigative Dermatology · 2023
    3. 591 A New 3D Skin Model Containing Autologous Immune Cells Reconstructed by Tissue Engineering Journal of Investigative Dermatology · 2019
    4. A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin Biofabrication · 2024 · 6 citations
    5. 3D organotypic skin models recapitulate autoantibody-driven pemphigus pathomechanisms and targeted therapeutic response Science Advances · 2026 · 1 citations
    6. Research Progress on Construction Technology of 3D Human Skin Models and Its Application Prospects in Dermatology International Journal of Molecular Sciences · 2026
    7. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025 · 3 citations
    8. Incorporation of hair follicles in 3D bioprinted models of human skin Science Advances · 2023 · 46 citations
    9. 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function Journal of Investigative Dermatology · 2017
    10. Disease-related biomarkers as experimental endpoints in 3D skin culture models Cytotechnology · 2023 · 3 citations
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