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    Glossary 3D Skin Models

    laboratory-engineered tissues that mimic human skin structure

    3D Skin Models, also known as Three-Dimensional Skin Constructs or 3D Skin Equivalents, are laboratory-engineered tissues that mimic the structure and function of human skin. These models are created using layers of different cell types, such as keratinocytes and fibroblasts, to replicate the epidermis and dermis. They are used in research and testing to study skin biology, disease, and the effects of cosmetics or pharmaceuticals, providing a more accurate alternative to traditional 2D cell cultures and reducing the need for animal testing.

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    1. Post-Treatment of Micro-Needling with a Dexpanthenol-Containing Ointment Accelerates Epidermal Wound Healing in Human 3D Skin Models Clinical Cosmetic and Investigational Dermatology · 2023 · 2 citations
    2. 1344 Novel human 3D skin model for skin aging research Journal of Investigative Dermatology · 2023
    3. 591 A New 3D Skin Model Containing Autologous Immune Cells Reconstructed by Tissue Engineering Journal of Investigative Dermatology · 2019
    4. A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin Biofabrication · 2024 · 6 citations
    5. 3D organotypic skin models recapitulate autoantibody-driven pemphigus pathomechanisms and targeted therapeutic response Science Advances · 2026 · 1 citations
    6. Research Progress on Construction Technology of 3D Human Skin Models and Its Application Prospects in Dermatology International Journal of Molecular Sciences · 2026
    7. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025 · 3 citations
    8. Incorporation of hair follicles in 3D bioprinted models of human skin Science Advances · 2023 · 46 citations
    9. 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function Journal of Investigative Dermatology · 2017
    10. Disease-related biomarkers as experimental endpoints in 3D skin culture models Cytotechnology · 2023 · 3 citations
    11. Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models Archives of Toxicology · 2018 · 38 citations
    12. Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis Biomedicines · 2020 · 26 citations
    13. Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening Advanced Healthcare Materials · 2025
    14. In Vitro Skin Models for Pigmentary Disorders: From Reconstructed Tissues to Skin-on-a-Chip Platforms Regenerative Biomaterials · 2026
    15. Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging Ageing Research Reviews · 2026
    16. Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles Burns & Trauma · 2021 · 65 citations
    17. Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments Journal of Investigative Dermatology · 2024 · 32 citations
    18. Microscopy‐guided laser ablation for the creation of complex skin models with folliculoid appendages Bioengineering & translational medicine · 2020 · 5 citations
    19. 605 3D-SeboSkin model application in Hidradenitis suppurativa/acne inversa Journal of Investigative Dermatology · 2019
    20. 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa Dermatology · 2021 · 4 citations
    21. Optimization of Gelatin and Crosslinker Concentrations in a Gelatin/Alginate-Based Bioink with Potential Applications in a Simplified Skin Model Molecules · 2025 · 8 citations
    22. 3D Printing of Skin Equivalents with Hair Follicle Structures and Epidermal‐Papillary‐Dermal Layers Using Gelatin/Hyaluronic Acid Hydrogels Chemistry - an Asian journal · 2022 · 18 citations
    23. The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression Journal of Visualized Experiments · 2011 · 110 citations
    24. Skin Organoids for Disease Modelling, Drug Screening and Regenerative Medicine: Recent Advances and Future Perspectives Wound Repair and Regeneration · 2026
    25. Improvement of Antioxidant Defences in Keratinocytes Grown in Physioxia: Comparison of 2D and 3D Models Oxidative Medicine and Cellular Longevity · 2023 · 9 citations
    26. Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis The EMBO Journal · 2021 · 25 citations
    27. 3D-Hautmodelle von Patienten mit Small Fiber Neuropathie Online Publication Service of Würzburg University (Würzburg University) · 2025
    28. 0887 Long-lived and genetically-diverse skin organoids derived from murine adult hair follicle stem cells Journal of Investigative Dermatology · 2025
    29. Bioengineered skin organoids: from development to applications Military Medical Research · 2023
    30. Montagna Symposium 2015: Harnessing Stem Cells to Reveal Novel Skin Biology and Disease Treatments Journal of Investigative Dermatology · 2016