Advancing Skin Model Development: A Focus on a Self-Assembled, Induced Pluripotent Stem Cell-Derived, Xeno-Free Approach

    January 2024 in “ Journal of Tissue Engineering ”
    Marla Dubau, Tarada Tripetchr, Lava Mahmoud … Burkhard Kleuser
    Studysummary In this study, researchers developed self-assembled skin models derived from hair follicle cells, offering an ethical and reliable alternative to animal testing and bovine collagen in dermatological research by providing functional dermal and epidermal layers for substance evaluation.
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    Research cited in this study 4

    1. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    2. Induced Pluripotent Stem Cell Line MUSIi006-A Derived from Hair Follicle Keratinocytes as a Non-Invasive Somatic Cell Source Stem cell research · 2018
    3. Induced Pluripotent Stem Cells From Human Hair Follicle Keratinocytes As A Potential Source For In Vitro Hair Follicle Cloning PeerJ · 2016
    4. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010