Three-Dimensional Cultured Human Dermal Papilla Cells in HGC-Coated Environments Enhance Hair Regeneration and Artificial Skin Integration

    January 2024 in “ Biomaterials Research
    Thuy Trang Truong, Hee-Jin Park, Kyoung Hwan Park, Jin Jung Song, Byoung‐Seok Lee, Kang Moo Huh, Sun‐Woong Kang
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    TLDR 3D-cultured cells in HGC-coated environments improve hair growth and skin integration.
    The study investigates the use of hexanoyl glycol chitosan (HGC) in 3D cultures of human dermal papilla (HDP) cells to enhance hair regeneration and integration into artificial skin models. HDP cells formed 3D spheroids that developed hair-like structures, and the addition of minoxidil and keratinocytes further enhanced hair growth. Transplanting these spheroids into artificial skin resulted in functional papilla structures, closely mimicking human skin. This research suggests that HGC-based 3D cultures could offer innovative approaches for hair loss treatment, cosmetic evaluations, and skin restoration therapies, highlighting the potential of 3D cell culture systems in dermatological research and clinical applications.
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