Skin Equivalent Assay: An Optimized Method for Testing Hair Growth Reconstitution Capacity of Epidermal and Dermal Cells

    January 2019 in “ Experimental Dermatology ”
    Seung Hwan Paik, Soon Jin Choi, Sunhyae Jang … Oh Sang Kwon
    Studysummary In this study, researchers developed a new 3D skin equivalent assay using mouse epidermal and dermal cells that successfully regenerated organized hair follicles, outperforming a 2D model in hair follicle orientation and quantity, and enhanced hair growth when Wnt3a was added.
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    Research cited in this study 14

    1. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017
    2. Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction Scientific Reports · 2016
    3. Wnt1a Maintains Characteristics of Dermal Papilla Cells That Induce Mouse Hair Regeneration in a 3D Preculture System Journal of Tissue Engineering and Regenerative Medicine · 2015
    4. Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells Stem Cells Translational Medicine · 2014
    5. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    6. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    7. Comparisons of Mouse Models for Hair Follicle Reconstitution Experimental Dermatology · 2011
    8. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    9. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    10. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    11. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    12. Bioengineering the Hair Follicle Organogenesis · 2007
    13. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    14. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 3

    1. Hair Follicle Units Improving the Construction of Tissue Engineered Skin In Vitro Journal of Tissue Engineering and Reconstructive Surgery · 2013
    2. Sheep Vibrissa Dermal Papillae Induce Hair Follicle Formation in Heterotypic Skin Equivalents British Journal of Dermatology · 1994
    3. Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified Development · 1992