Can an In Vitro Hair Drug Model Be Developed Using Dermal Papilla Cells Alone?

February 2021 in “ Experimental dermatology ”

Tze Chiun Lim, Meng Fatt Leong, Hongfang Lu, Chan Du, Andrew C.A. Wan

dermal papilla cells DP cells PDMS molds spheroids hair growth pathways catagen-inducing dexamethasone anagen-inducing cyclosporin A minoxidil bimatoprost epithelial–mesenchymal interactions hair follicles Rogaine Latisse

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Bimatoprost →

a synthetic prostamide used to treat eyelashes also shows promise for stimulating hair growth on scalp

Studysummary This study observed that using 3D dermal papilla microtissues enhances hair follicle regeneration and gene expression compared to 2D cultures, indicating their potential for hair growth drug screening.

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