Regenerative Cosmetics: Skin Tissue Engineering for Anti-Aging, Repair, and Hair Restoration

This review evaluates recent advancements in hair follicle bioengineering and discusses the potential for developing effective treatments for hair loss through tissue engineering, despite current challenges in creating functional cultured human hair cells.

This study reviewed the physiological and psychological impacts of acne vulgaris, highlighting its complex interactions with endocrine issues, sebum production, and immune response, while suggesting that a multidisciplinary approach can inform future treatments and improve quality of life for those affected.

This study highlights the lack of sufficient Korean epidemiological research examining the psychosocial aspects of female pattern hair loss, the leading cause of hair loss among women.

In this study, researchers reported promising initial results in developing future cosmetic technologies that could transform hair styling by altering hair from within, offering alternatives to current methods.

In this study, researchers used 3D bioprinting to successfully create engineered skin tissues with hair follicle-like structures, potentially enhancing skin grafts and safety testing for chemical compounds by more closely mimicking natural skin complexity.

This systematic review concluded that mesotherapy shows potential for improving hair growth outcomes, yet lacks standardized regimens and requires further large-scale trials to establish its efficacy and safe use.

This study found that human scalp hair significantly reduces solar radiation intake, with more tightly curled hair offering greater protection against heat gain compared to a naked scalp.

This study reviews the roles and mechanisms of MSC-derived exosomes in wound healing, noting their potential as promising cell-free therapies for cutaneous regeneration.

This narrative review discusses carboxytherapy, highlighting its potential benefits in treating various dermatologic and cosmetic conditions such as skin aging, cellulite, and alopecia. Reportedly, this minimally-invasive treatment facilitates skin rejuvenation through vasodilatation and collagen reorganization.

This review discusses the potential role of exosomes in aesthetic medicine for skin rejuvenation and hair restoration, but reports no new clinical findings and emphasizes the need for further studies with regulatory oversight.

This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.

In this study, researchers used a new method with platelet-rich plasma-loaded microcarriers to enhance dermal papilla cell activity and hair follicle regeneration, achieving significant hair and vessel growth in a mouse model compared to control groups.

This review discusses the role of proteomics in understanding skin diseases such as cancers and psoriasis, with findings suggesting cell death and metabolism as major areas of focus, but reports no new experimental results.

This review explores skin microbiome composition and its ecological interactions, highlighting the role of host and environmental factors in shaping the microbial community, but provides no new research findings.

This study found that GelMA/HAMA bioink shows promise for 3D printing skin equivalents, as it effectively mimics the native skin's properties and supports hair follicle structure development.

This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

This review covers the structure, development, cycle, and molecular regulation of hair follicles but does not report new results, aiming to offer insights for addressing hair follicle-related diseases.

This study demonstrated that a 3D bioprinting technique using a gelatin/alginate hydrogel scaffold can regenerate entire hair follicles in mice, offering potential advancements in hair loss treatment.

This study concluded that mesotherapy appears effective for treating pattern hair loss, but emphasizes a need for more research comparing it to other treatments due to limited sample sizes.

This review examines the definition, classification, mechanism, clinical efficacy for hair regrowth, and potential adverse effects of platelet rich plasma, but does not present new experimental results.

This review examines current and potential tissue engineering strategies for hair follicle regeneration in androgenetic alopecia but does not provide new clinical results, highlighting the need for further research and development.

This review reports that clinical studies generally showed favorable results for microneedling as an adjunct therapy for androgenic alopecia and alopecia areata, despite the low quality of existing data.

This review explains the evolution and current techniques of follicular unit transplantation for hair restoration, identifying conditions suitable for surgery and offering guidelines for dermatologists to assess candidate suitability, focusing on male and female pattern hair loss.

This review examines how mesenchymal stem cells and their derivatives may enhance skin regeneration and rejuvenation, but it reports no new clinical results; the authors suggest iPSC-derived MSCs hold promise for future therapies.

This review found that despite varied levels of stigmatization reported in studies, hair loss generally leads to stigmatization and a reduced quality of life, but specific research on this stigma is limited.

This review discusses the use of microneedling for androgenetic alopecia and finds it promising for enhancing hair density and thickness, especially when combined with other treatments, but notes no standardized protocol exists yet.

This study reports that using activated platelet-rich plasma releasate in the preparation of bioengineered hair follicle germs enhanced follicular gene expression and significantly improved hair regeneration in vitro.

This review discusses the pathophysiology, diagnosis, systemic associations, and treatments for female pattern hair loss and reports no new clinical findings.

This review discusses the potential of stem cell-based therapies, particularly involving stem cell-derived conditioned medium and exosomes, for hair regeneration in nonscarring alopecia, but it reports no new clinical outcomes.

In this double-blind, randomized controlled trial, researchers found that cow placenta extract lotion was as effective as topical minoxidil 2% in increasing hair count for women with androgenetic alopecia over six months, though the mean increases in hair count were similar for both treatments.

This review discusses pharmacologic and non-pharmacologic treatments for androgenetic alopecia, noting that current medications like finasteride and minoxidil can slow hair loss but only partially restore hair growth, with early treatment offering better outcomes.

This study reported that a novel chitosan/polyvinyl alcohol nanofiber sponge effectively enhances the hair follicle-inducing ability of dermal papilla multicellular spheroids in a mouse model.

This review discusses the current challenges and strategies in hair follicle bioengineering for treating hair loss and reports no new clinical results; it highlights ongoing hurdles and future directions for developing functional hair regeneration therapies.

This review discusses the physiopathology of androgenetic alopecia and evaluates various traditional and emerging treatments, reporting no new clinical results but highlighting the need for enhanced treatment strategies.

This study found that the human placenta extracellular matrix hydrogel restored the hair-inductive capacity of high-passaged dermal papilla cells, enabling them to regenerate new hair follicles when co-grafted with mouse epidermal cells.

This study developed a method for generating germ-like tissues called bbHFGs, which efficiently promoted hair follicle formation in mice, potentially advancing hair regenerative medicine applications.

This review discusses the impact of age-related hair changes on perceived attractiveness and self-perception, emphasizing the need for holistic anti-aging consultations that include hair preservation strategies.

In this study, growing human hair follicles in a defined glycosaminoglycan hydrogel ex vivo promoted cell survival, proliferation, and activation of hair growth-related signaling pathways, suggesting GAG-based hydrogels could modulate the hair follicle growth cycle.

This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.

This review discusses the cosmetic and nutricosmetic efficacy of hyaluronic acid for skin rejuvenation and reports that HA formulations show remarkable anti-aging properties.

This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.

This article discusses advancements in hair restoration, highlighting the use of robotics and follicular unit extraction along with adjuvant therapies like platelet-rich plasma, but presents no new clinical findings.