Exosomes: The Latest in Regenerative Aesthetics

January 2023 in “ Regenerative Medicine ”

Krishna S. Vyas, Joely Kaufman, Girish S. Munavalli, Kiran Robertson, Atta Behfar, Saranya P. Wyles

exosomes extracellular vesicles skin aging tissue homeostasis hair restoration

TLDR Exosomes show promise for skin and hair rejuvenation, but more research and regulation are needed before they can be widely used.

The document "Exosomes: the latest in regenerative aesthetics" discusses the emerging role of exosomes, or extracellular vesicles, in regenerative aesthetic medicine. These nano-sized vesicles, which play crucial roles in intercellular communication, are being used to target the root causes of skin aging and improve tissue homeostasis. However, there are considerations for their use, including variation in exosome purification, isolation, storage, scalability, and reproducibility. The current research literature does not provide a clear consensus on long-term use for skin rejuvenation or hair restoration, nor does it specify which patients would benefit most from this technology. The document concludes that more clinical studies with proper regulatory oversight are needed, and notes that there are currently no US FDA-approved exosome products on the market for medical indications.

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Research cited in this study

7 / 7 results

research Extracellular Vesicles in Facial Aesthetics: A Review

8 citations, June 2022 in “International Journal of Molecular Sciences”

Tiny particles called extracellular vesicles show promise for skin improvement and anti-aging in facial care but face challenges like low production and lack of research.

research Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase

5 citations, March 2022 in “Frontiers in Cell and Developmental Biology”

Colostrum-derived exosomes can promote hair growth and may be a promising treatment for hair loss.

research The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics

38 citations, June 2019 in “International Journal of Molecular Sciences”

Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.

Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations, March 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations, January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations, April 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations, November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

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Exosomes: The Latest in Regenerative Aesthetics

Research cited in this study

research Extracellular Vesicles in Facial Aesthetics: A Review

research Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase

research The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

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