Cell-Based Model Systems for Validation of Efficacy Claims for Cosmetic Ingredients

October 2022 in “ Cosmetics ”

Prachi Singh, Shruthi S. Bhat, Nikhil Kumar Singh, Babu U. Venkanna, Mohamed Rafiq, Raghavendra P. Rao

hair growth 5-alpha reductase human follicle dermal papilla cells outer root sheath cells skin aging anti-oxidant anti-inflammatory gene expression skin hydration skin rejuvenation barrier function psoriasis wound healing hyperpigmentation dermal papilla cells

Studysummary This article reviews in-vitro and cell-free methods for assessing the efficacy of herbal ingredients in cosmetic formulations for skin health and hair growth, but it reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discusses the use of cell-based model systems to validate the efficacy of cosmetic ingredients, particularly those promoting hair growth and skin health. Hair growth is influenced by the proliferation of certain cells and the inhibition of the enzyme 5-alpha reductase. The document also discusses the use of human follicle dermal papilla cells and outer root sheath cells to assess the effectiveness of cosmetic ingredients on hair growth. Skin aging is evaluated through cell-based assays based on anti-oxidant and anti-inflammatory activities, gene expression levels, and the effect on certain enzymes. The document also discusses the use of cell-based models to evaluate skin hydration, rejuvenation, barrier function, psoriasis, wound healing, and hyperpigmentation. The document also highlights the benefits and limitations of cell-based assays in screening cosmetic products.

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