The Clock Gene Brain And Muscle Arnt-Like Protein-1 (BMAL1) Is Involved In Hair Growth

In 2013, researchers discovered that the clock gene BMAL1 is involved in hair growth regulation. Mice without BMAL1 showed delayed hair regrowth, and knocking down BMAL1 in human dermal papilla cells affected hair growth-related gene expression. The study highlighted the circadian rhythm in hair follicles and suggested that BMAL1 influences androgen receptor gene expression, which could be significant for treating androgenetic alopecia (AGA). The potential for chronotherapy in AGA treatment was also discussed, proposing that synchronizing treatment with AR expression peaks might improve outcomes. The exact number of subjects used in the study was not provided.