The Clock Gene Brain And Muscle Arnt-Like Protein-1 (BMAL1) Is Involved In Hair Growth

August 2013 in “ Archives of Dermatological Research ”

Yuichi Watabe, Miyuki Tomioka, Ai Watabe, Masaki Aihara, Shigeki Shimba, Hajime Inoue

BMAL1 clock gene hair growth regulation dermal papilla cells circadian rhythm hair follicles androgen receptor androgenetic alopecia chronotherapy AR expression hair growth AGA

Studysummary This study concluded that the expression of clock genes, specifically BMAL1, in hair follicles is linked to circadian rhythm, and BMAL1 regulates hair growth.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

In 2013, researchers discovered that the clock gene BMAL1 is involved in hair growth regulation. Mice without BMAL1 showed delayed hair regrowth, and knocking down BMAL1 in human dermal papilla cells affected hair growth-related gene expression. The study highlighted the circadian rhythm in hair follicles and suggested that BMAL1 influences androgen receptor gene expression, which could be significant for treating androgenetic alopecia (AGA). The potential for chronotherapy in AGA treatment was also discussed, proposing that synchronizing treatment with AR expression peaks might improve outcomes. The exact number of subjects used in the study was not provided.

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