A New Label-Free Screen for Steroid 5α-Reductase Inhibitors Using LC-MS

October 2016 in “ Steroids ”

Jukkarin Srivilai, Karma Rabgay, Nantaka Khorana, Neti Waranuch, Nitra Nuengchamnong, Kornkanok Ingkaninan

steroid 5α-reductase LC-MS androgenic alopecia Impatiens balsamina Curcuma longa S5aR anti-androgenic compounds liquid chromatography-mass spectrometry S5aR inhibitors hair loss herbal extracts

Studysummary This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

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