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research Anti-Androgen Effects of Extracts and Compounds fromGanoderma lucidum

20 citations , February 2009 in “Chemistry & Biodiversity”

This study found that Ganoderma lucidum extracts showed weak 5alpha-reductase inhibition but significantly inhibited prostate cell proliferation and testosterone-driven prostate growth in rats, suggesting potential as an ingredient for treating androgen-induced diseases.

research Stability studies of antiandrogenic compounds in Curcuma aeruginosa Roxb. extract

10 citations , June 2014 in “Journal of Pharmacy and Pharmacology”

This study found that antiandrogenic compounds in Curcuma aeruginosa, including germacrone, degrade rapidly at high temperatures but are more stable when solubilized in PEG-40.

research Virtual Screening of Compounds in Candlenut and Aloe Vera against Androgen Receptor (PDB ID:4K7A) for Anti-Hair Loss

September 2026 in “Research Journal of Pharmacy and Technology”

This study found that compounds from candlenut and Aloe vera showed promising anti-alopecia potential by binding effectively to the androgen receptor in a molecular docking analysis, suggesting further research is necessary.

research Molecular Docking and Molecular Dynamics Analysis of Phytochemical Compounds from Nutmeg Fruit (Myristica fragrans Houtt.) on Androgen Receptor (4K7A) as Anti-Alopecia Therapy

December 2025 in “Fullerene Journal of Chemistry”

This study investigated the potential of nutmeg-derived phytochemicals as anti-alopecia agents using molecular docking and simulations, finding that geranylgeraniol exhibited significant binding stability and potential efficacy against androgenetic alopecia comparable to finasteride and superior to minoxidil.

research Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract

9 citations , June 2022 in “Plants”

This study found that shallot extract may promote hair growth in androgenetic alopecia by reducing inflammation and modulating gene expression related to key hair growth pathways.

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Community Join

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community Which compounds in Saw Palmetto are actually beneficial?

4 upvotes 1 year ago

Saw palmetto's fatty acids, particularly lauric and linoleic acids, inhibit enzymes linked to hair loss, while sterols like beta-sitosterol are less effective due to poor absorption. The conversation questions which specific compounds in saw palmetto contribute to its anti-androgenic effects.

community The story of RU58841/PSK3841

in Research/Science 2 years ago

RU58841, an anti-androgenic compound, showed early promise for treating alopecia but faced challenges after its patent in 1997. Despite advancing to Phase II trials, safety concerns and financial struggles led Aventis to abandon its development. Proskelia, which later merged into ProStrakan, couldn't prioritize the drug, leading to its eventual stagnation and failure to reach the market.

community No access to RU, Pyri. Any alternative anti androgen?

in Treatment 4 upvotes 1 year ago

The conversation discusses alternatives to RU58841 for hair loss treatment, with suggestions including topical spironolactone, peppermint and rosemary oils, and saw palmetto. The user also considers ordering RU58841 from China but finds it too expensive.

community What's the best/"safest" topical anti androgen on the market currently?

1 upvotes 1 year ago

The user experienced decreased libido with saw palmetto and is now considering topical anti-androgens like RU58841, pyrilutamide, and topical dutasteride for hair loss. Minoxidil is also mentioned as a potential addition, but the user is cautious about side effects and availability of treatments.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

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Learn

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learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in both men and women, but it is not approved for hair loss anywhere; the company reports that its China Phase III trial in men met its primary endpoint, but the data come from sponsor announcements rather than peer-reviewed journals, and long-term safety is unknown.

learn Lavender

plant and natural oil with antimicrobial and some anti-androgenic effects

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Cetirizine

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

learn Rosemary

herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn HMI-115

HMI-115: Frequently Asked Questions About Hair Loss Treatment HMI-115 is an investigational anti-prolactin-receptor antibody being trialled for androgenetic alopecia. It is not approved anywhere; its hair-loss evidence is a 16-person Phase 1b announced only by press release, plus a completed 192-man Phase 2 in China whose results are not yet published.

learn Baicapil

Struggling with patchy hair loss like alopecia areata? Baicapil might help by reducing inflammation and reactivating growth. There is no published trial of Baicapil in alopecia areata. The anti-inflammatory and hair-density claims come from the ingredient's manufacturer and from laboratory work on its plant extracts, in people with androgenetic-type hair loss rather than autoimmune patchy hair loss.

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Clinics

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All 77 clinic results →

Experts

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Dermatologist
Andi Iryanti, M. Biomed
Indonesia

Andi Iryanti, M. Biomed