Cutaneous Permeation And Penetration Of Sunscreens: Formulation Strategies And In Vitro Methods
December 2017
in “
Cosmetics
”
cutaneous permeation sunscreens formulation strategies in vitro methods systemic absorption DNA damage UV filters nanotechnology three-dimensional human skin cultures encapsulation lipid nanoparticles bioadhesive nanoparticles skin penetration photoprotection standardized in vitro methods in vivo performance regulatory compliance skin absorption sunblock UV protection nano particles 3D skin models lipid-based particles bioadhesive particles sun protection regulatory standards
TLDR Effective sunscreen formulations can reduce skin absorption and enhance protection.
The document reviewed in vitro studies on sunscreen permeation and retention, emphasizing the importance of formulation strategies to prevent systemic absorption and potential DNA damage. It discussed the effectiveness and stability of various UV filters, the impact of nanotechnology, and the use of three-dimensional human skin cultures as alternatives to animal testing. Techniques like encapsulation in lipid nanoparticles and bioadhesive nanoparticles were found to reduce skin penetration and enhance photoprotection. The review highlighted the need for standardized in vitro methods to predict in vivo performance and ensure regulatory compliance.
