Optimization of Lipid-Based Nanoformulation for Cutaneous Targeting: Niosomes as Potential Candidates

May 2023 in “ European journal of pharmaceutical sciences ”

Yin-Ku Lin, Chien‐Yu Hsiao, Abdullah Alshetaili, Ibrahim A. Aljuffali, Enli Chen, Jia‐You Fang

lipid-based nanoformulations niosomes cutaneous targeting skin-targeted drug delivery skin deposition systemic absorption hair follicle uptake antioxidant ability phospholipid content inflammatory skin diseases alopecia acne drug solubility follicular uptake skin irritation skin diseases hair loss

Studysummary This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study evaluated various lipid-based nanoformulations for skin-targeted drug delivery, finding niosomes to be the most effective. Niosomes showed superior skin deposition, reduced systemic absorption, enhanced hair follicle uptake, and increased antioxidant ability, particularly with higher phospholipid content. They demonstrated significant potential for treating inflammatory skin diseases, alopecia, and acne by improving drug solubility and follicular uptake, with minimal skin irritation observed in vivo. The findings suggest that niosomes are promising candidates for efficient cutaneous drug delivery, though further clinical validation is needed.

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