TLDR Niosomes are the most effective at delivering drugs to the skin with minimal absorption into the body.
The study evaluated various lipid-based nanoformulations for skin-targeted drug delivery, finding niosomes to be the most effective. Niosomes showed superior skin deposition, reduced systemic absorption, enhanced hair follicle uptake, and increased antioxidant ability, particularly with higher phospholipid content. They demonstrated significant potential for treating inflammatory skin diseases, alopecia, and acne by improving drug solubility and follicular uptake, with minimal skin irritation observed in vivo. The findings suggest that niosomes are promising candidates for efficient cutaneous drug delivery, though further clinical validation is needed.
149 citations,
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April 2016 in “Research and reports in transdermal drug delivery” Transfollicular drug delivery is promising but needs more research to improve and understand it better.
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August 2020 in “Drug Design Development and Therapy” Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.
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October 2023 in “Molecular cancer” New treatments like nanotechnology show promise in improving skin cancer therapy.
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Plant-based compounds can improve wound dressings and skin medication delivery.
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June 2020 in “Pharmaceutics” New nanocarriers improve drug delivery for disease treatment.
