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Optimization of Lipid-Based Nanoformulation for Cutaneous Targeting: Niosomes as Potential Candidates

research Lipid-based nanoformulation optimization for achieving cutaneous targeting: Niosomes as the potential candidates to fulfill this aim

6 citations , May 2023 in “European journal of pharmaceutical sciences”

This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.

research Targeting the Hypoxic Microenvironment in Cutaneous Chronic Graft-Versus-Host Disease through PI3Kδ Inhibition

1 citations , November 2024 in “Blood”

This study found that inhibiting the PI3Kδ enzyme in murine models of cutaneous chronic graft-versus-host disease (cGVHD) reduced skin scores and fibrosis, prevented pathogenic lymphoid structures, and improved survival, suggesting it as a promising therapeutic approach to address the disease's hypoxic pathophysiology.

research 572 Development of immunotherapies targeting TCR-Vβ2 for treatment of cutaneous T cell lymphoma

July 2024 in “Journal of Investigative Dermatology”

Targeting TCR-Vβ2 in cutaneous T cell lymphoma shows promise for safer, more specific treatment.

research Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal?

28 citations , January 2017 in “EBioMedicine”

This study discusses potential anti-inflammatory roles of endocannabinoid system modulation and phytocannabinoids in skin health, but reports no new clinical results; the authors emphasize the need for further clinical exploration.

Targeting Noncanonical Nuclear Factor Kappa B Signaling in CYLD Cutaneous Syndrome by Selective Inhibition of IκB Kinase Alpha

research Targeting noncanonical nuclear factor kappa B signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha

June 2026 in “Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)”

In this study, researchers found that inhibiting IKKα in patient-derived CCS tumour models reduces tumour viability, supporting the potential for topical IKKα inhibitors as a treatment for CCS.

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community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

110 upvotes 2 years ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community My experimental hair loss journey under medical supervision: finasteride/dutasteride, oral/topical minoxidil+tretinoin (3-month progress and hair transplant insights for those considering it)

in Treatment 43 upvotes 1 year ago

A 23-year-old discusses their hair loss treatment using finasteride, dutasteride, oral and topical minoxidil, and topical tretinoin under medical supervision. They stress stabilizing hair loss before a hair transplant and plan to continue the regimen for at least 18 months.

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Hair Loss Treatments
DCSI - Dermatology & Cutaneous Surgery InstituteWellington, FL · US

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