Analysis of Genome DNA Methylation at Inherited Coat-Color Dilutions of Rex Rabbits

    January 2020 in “ Research Square (Research Square) ”
    Yang Chen, Shuaishuai Hu, Ming Liu, Bohao Zhao, Neng Yang, Jiali Li, Qiuran Chen, Juan Zhou, Guolian Bao, Xinsheng Wu
    Image of study
    TLDR Inherited color dilution in Rex rabbits is linked to DNA methylation changes in hair follicles.
    The study investigated genome-wide DNA methylation in Rex rabbit hair follicles to understand the epigenetic regulation of coat-color dilution. By comparing Chinchilla (Ch) and diluted Chinchilla (DCh) groups using whole-genome bisulfite sequencing, researchers found that 3.5% of cytosine sites were methylated, with CG methylation being the most common. They identified 126,405 differentially methylated regions (DMRs) and 11,459 DMR-associated genes (DMGs), which were mainly involved in pigmentation development and Wnt signaling pathways. Verification through bisulfite treatment and qRT-PCR confirmed the reliability of the data. The findings highlighted a significant link between inherited color dilution and DNA methylation changes in rabbit hair follicles.
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