TLDR Inherited color dilution in rabbits is linked to DNA methylation changes.
The study analyzed DNA methylation patterns in Rex rabbits with inherited coat color dilutions, identifying 126,405 differentially methylated regions (DMRs) associated with 11,459 genes involved in pigmentation and Wnt signaling pathways. Despite a small sample size (n=6), the findings suggested that DNA methylation played a significant role in regulating genes responsible for coat color, providing insights into the epigenetic mechanisms of rabbit pigmentation. Verification through bisulfite sequencing PCR and qRT-PCR confirmed the reliability of the data, highlighting the potential of methylation sites as epigenetic biomarkers for coat color dilution.
7 citations,
January 2021 in “Frontiers in genetics” Inherited color dilution in rabbits is linked to DNA methylation changes.
1 citations,
January 2020 in “Research Square (Research Square)” Inherited color dilution in Rex rabbits is linked to DNA methylation changes in hair follicles.
28 citations,
August 2018 in “BMC genomics” DNA methylation changes are linked to hair growth cycles in goats.
24 citations,
April 2020 in “Cells” DNA methylation and long non-coding RNAs are key in controlling hair growth in Cashmere goats.
1 citations,
January 2020 in “Research Square (Research Square)” Inherited color dilution in Rex rabbits is linked to DNA methylation changes in hair follicles.
1 citations,
July 2023 in “Journal of Animal Science and Biotechnology” The SOSTDC1 gene is crucial for determining sheep wool type.
10 citations,
May 2019 in “Seminars in Cell & Developmental Biology” Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.
