Analysis of Genome DNA Methylation at Inherited Coat Color Dilutions of Rex Rabbits

    January 2021 in “ Frontiers in genetics ”
    Yang Chen, Shuaishuai Hu, Ming Liu, Bohao Zhao, Neng Yang, Jiali Li, Qiuran Chen, Juan Zhou, Guolian Bao, Xinsheng Wu
    TLDR Inherited color dilution in rabbits is linked to DNA methylation changes.
    The study analyzed DNA methylation patterns in Rex rabbits with inherited coat color dilutions, identifying 126,405 differentially methylated regions (DMRs) associated with 11,459 genes involved in pigmentation and Wnt signaling pathways. Despite a small sample size (n=6), the findings suggested that DNA methylation played a significant role in regulating genes responsible for coat color, providing insights into the epigenetic mechanisms of rabbit pigmentation. Verification through bisulfite sequencing PCR and qRT-PCR confirmed the reliability of the data, highlighting the potential of methylation sites as epigenetic biomarkers for coat color dilution.
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