The Complex Relationship Between TFEB Transcription Factor Phosphorylation and Subcellular Localization

May 2018 in “ EMBO journal ”

Rosa Puertollano, Shawn M. Ferguson, James Brugarolas, Andrea Ballabio

TFEB phosphorylation subcellular localization mTORC1 calcineurin autophagy lysosomal biogenesis cellular clearance cellular stress responses

TLDR Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

The document explored the intricate relationship between the phosphorylation of the TFEB transcription factor and its subcellular localization. It highlighted how TFEB's activity and location within the cell were regulated by various signaling pathways, including mTORC1, which prevented TFEB's nuclear transport, and calcineurin, which promoted it. The study also discussed the role of TFEB in autophagy, lysosomal biogenesis, and cellular clearance, emphasizing its importance in cellular stress responses and disease mechanisms, such as cancer and neurodegenerative disorders. The findings underscored the potential of targeting TFEB pathways for therapeutic interventions.

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