The Suppression Effects of Fat Mass and Obesity Associated Gene on Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocytes by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor

February 2023 in “ International Journal of Stem Cells ”

Zhiwei Shang, Haixia Feng, Liye Xia

Fat Mass and Obesity Associated gene hair follicle-derived neural crest stem cells melanocytes microphthalmia-associated transcription factor N6-methyladenosine FTO gene NCSCs MCs Mitf m6A

TLDR The FTO gene hinders stem cells in hair follicles from becoming pigment cells.

The study found that the Fat Mass and Obesity Associated (FTO) gene suppressed the ability of hair follicle-derived neural crest stem cells (NCSCs) to differentiate into melanocytes (MCs) through the modification of the microphthalmia-associated transcription factor (Mitf) by N6-methyladenosine (m6A). This suggests that FTO played a role in regulating the differentiation process of these stem cells into melanocytes, which are crucial for pigmentation.

View this study on ijstemcell.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis

11 citations , February 2019 in “Stem cells international”

Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.

research Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids

169 citations , January 2018 in “Cell Reports”

Scientists grew hair follicles from mouse stem cells in a lab setting.

research Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation

240 citations , April 2011 in “Pigment Cell & Melanoma Research”

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Related Community Posts Join

6 / 910 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 2 years ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 1 year ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).

in Research/Science 295 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.

community Is this true? Is long term taking fin harmful to the liver?

in Chat 127 upvotes 2 years ago

The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

community Anyone else realize how many younger guys are balding?

in Chat 262 upvotes 1 year ago

Many younger men are experiencing hair loss due to genetics, diet, stress, and lifestyle changes. Treatments like finasteride and minoxidil are mentioned, with some users noting improvements.

Similar Research

5 / 1000+ results

research Erasing the Methyl Mark: Histone Demethylases at the Center of Cellular Differentiation and Disease

667 citations , May 2008 in “Genes & Development”

Histone demethylases can change gene expression and may be linked to diseases like cancer.

research Friends Turned Foes: Angiogenic Growth Factors Beyond Angiogenesis

24 citations , October 2017 in “Biomolecules”

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

research The Role of Leptin in Selected Skin Diseases

16 citations , October 2020 in “Lipids in Health and Disease”

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

research ALKBH5-Mediated m6A Demethylation Fuels Cutaneous Wound Re-Epithelialization by Enhancing PELI2 mRNA Stability

8 citations , July 2023 in “Inflammation and Regeneration”

ALKBH5 helps wounds heal faster by stabilizing PELI2 mRNA.