The Suppression Effects of Fat Mass and Obesity Associated Gene on Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocytes by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor

    February 2023 in “ International Journal of Stem Cells ”
    Zhiwei Shang, Haixia Feng, Liye Xia
    Studysummary The FTO gene hinders stem cells in hair follicles from becoming pigment cells. Our plain-language summary of this paper — not a Tressless recommendation.
    The study found that the Fat Mass and Obesity Associated (FTO) gene suppressed the ability of hair follicle-derived neural crest stem cells (NCSCs) to differentiate into melanocytes (MCs) through the modification of the microphthalmia-associated transcription factor (Mitf) by N6-methyladenosine (m6A). This suggests that FTO played a role in regulating the differentiation process of these stem cells into melanocytes, which are crucial for pigmentation.
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