Coordinating Stem Cell Behavior In The Hair Follicle

September 2025 in “ Digital Commons - RU (Rockefeller University) ”

Chiung-Ying Chang

hair follicle stem cells HFSCs melanocyte stem cells McSCs nuclear factor I/B Nfib hair follicle morphogenesis wound repair hair cycle stem cell proliferation stem cell differentiation

TLDR Nfib in hair follicle stem cells boosts melanocyte stem cell growth and differentiation.

The study explores the coordination between epithelial hair follicle stem cells (HFSCs) and melanocyte stem cells (McSCs) in hair follicles, focusing on the role of the transcription factor NFIB. While NFIB is crucial for hair follicle morphogenesis and wound repair, its ablation in adult HFSCs does not affect their maintenance or the hair cycle. Surprisingly, NFIB loss in HFSCs enhances the proliferation and differentiation of nearby McSCs. These findings highlight the complex interplay between HFSCs and McSCs and suggest that their cooperative behavior can be disrupted in conditions like injury, stress, and disease.

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