Cell of Origin Contributes to Melanoma Diversity
May 2018
in “
Journal of Investigative Dermatology
”
dermal white adipose tissue hair growth stem cell clusters corneal epithelium scarring alopecias PPAR-y modulator macrophages frontal fibrosing alopecia Lichen planopilaris melanocyte stem cells hair follicle nestin-positive multipotent stem cells androgenetic alopecia gene expression profiles scalp regions PPAR-gamma modulator FFA LPP AGA
TLDR Different types of stem cells in the skin contribute to the variety of melanoma forms.
The document summarizes findings from a dermatology conference, highlighting the role of dermal white adipose tissue in hair growth, the identification of stem cell clusters in the corneal epithelium, and a potential new treatment for scarring alopecias using a PPAR-y modulator. It also discusses the differing roles of macrophages in frontal fibrosing alopecia and Lichen planopilaris, suggesting possible targeted treatments. Specifically, it reports that melanocyte stem cells in the hair follicle and nestin-positive multipotent stem cells in the dermis contribute to the diversity of melanoma, leading to different tumor phenotypes and treatment responses. Additionally, a study on androgenetic alopecia shows different gene expression profiles in various scalp regions, which may explain the susceptibility to this condition.
