Cell of Origin Contributes to Melanoma Diversity

    April 2018 in “ Journal of Investigative Dermatology ”
    Qi Sun, W. Lee, Makoto Takeo, Churlzu Lim, Xiaowei Xu, Rana S. Moubarak, Peggy Myung, M. Mark Taketo, Iman Osman, Emi K. Nishimura, Mayumi Ito
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    TLDR Different types of stem cells in the skin contribute to the variety of melanoma forms.
    The document summarizes findings from a dermatology conference, highlighting the role of dermal white adipose tissue in hair growth, the identification of stem cell clusters in the corneal epithelium, and a potential new treatment for scarring alopecias using a PPAR-y modulator. It also discusses the differing roles of macrophages in frontal fibrosing alopecia and Lichen planopilaris, suggesting possible targeted treatments. Specifically, it reports that melanocyte stem cells in the hair follicle and nestin-positive multipotent stem cells in the dermis contribute to the diversity of melanoma, leading to different tumor phenotypes and treatment responses. Additionally, a study on androgenetic alopecia shows different gene expression profiles in various scalp regions, which may explain the susceptibility to this condition.
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