The Importance of Myeloid-Derived Suppressor Cells in Regulating Autoimmune Effector Cells in Chronic Contact Eczema

    October 2007 in “ The Journal of Immunology ”
    Rachid Marhaba, Mario Vitacolonna, Dagmar Hildebrand … Margot Zöller
    Studysummary This study found that chronic eczema supports the expansion of myeloid suppressor cells, which contribute to silencing autoreactive T cells and partially promote hair regrowth in alopecia areata.
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    Research cited in this study 7

    1. In Vivo CD44-CD49d Complex Formation in Autoimmune Disease Has Consequences on T Cell Activation and Apoptosis Resistance European Journal of Immunology · 2006
    2. A Chronic Contact Eczema Impedes Migration of Antigen-Presenting Cells in Alopecia Areata Journal of Investigative Dermatology · 2006
    3. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005
    4. Management of Hair Loss Dermatologic Clinics · 2005
    5. Chronic Delayed-Type Hypersensitivity Reaction as a Means to Treat Alopecia Areata Clinical & Experimental Immunology · 2004
    6. Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss Veterinary pathology · 2003
    7. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998