Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing

    July 2023 in “ Stem Cells Translational Medicine ”
    Mengting Zhu, Lijuan Cao, Sonia Melino, Eleonora Candi, Ying Wang, Changshun Shao, Gerry Melino, Yufang Shi, Xiao Chen
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    TLDR Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.
    The document discusses the role of Mesenchymal Stem/Stromal Cells (MSCs) in wound healing, tissue regeneration, and cancer progression. MSCs interact with immune cells to modulate inflammation during wound healing and can differentiate into various skin cell types, including those that form hair follicles. However, the functionality of these differentiated cells remains unknown. In cancer, MSCs contribute to tumor growth by maintaining an immunosuppressive environment. The document also presents studies showing the therapeutic potential of MSCs in treating chronic refractory wounds, with positive outcomes such as improved healing rates and reduced hospitalization periods. Case studies also show successful use of MSCs in treating radiation burns, perianal fistulas, and pressure ulcers. Despite promising results, the underlying mechanisms of MSCs in wound healing are not fully understood, and challenges such as immune rejection and dosage need to be addressed for effective clinical application.
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