Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing

    July 2023 in “ Stem Cells Translational Medicine ”
    Mengting Zhu, Lijuan Cao, Sonia Melino, Eleonora Candi, Ying Wang, Changshun Shao, Gerry Melino, Yufang Shi, Xiao Chen
    Image of study
    TLDR Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.
    The document discusses the role of Mesenchymal Stem/Stromal Cells (MSCs) in wound healing, tissue regeneration, and cancer progression. MSCs interact with immune cells to modulate inflammation during wound healing and can differentiate into various skin cell types, including those that form hair follicles. However, the functionality of these differentiated cells remains unknown. In cancer, MSCs contribute to tumor growth by maintaining an immunosuppressive environment. The document also presents studies showing the therapeutic potential of MSCs in treating chronic refractory wounds, with positive outcomes such as improved healing rates and reduced hospitalization periods. Case studies also show successful use of MSCs in treating radiation burns, perianal fistulas, and pressure ulcers. Despite promising results, the underlying mechanisms of MSCs in wound healing are not fully understood, and challenges such as immune rejection and dosage need to be addressed for effective clinical application.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 13 results

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 1 year ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

      community Mesenchymal Stem Cell Therapy (Exosome) Before & After

      in Treatment  2 upvotes 7 months ago
      A user's father experienced hair regrowth and other health improvements after two IV exosome treatments. The user also had four rounds of exosome therapy, noting significant hair regrowth and relief from headaches, but no change in gray hair.

      community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

      in Progress Pictures  26 upvotes 9 months ago
      A user shared their 1.5-year hair restoration journey, successfully using mesenchymal stem cell therapy, Platelet Rich Plasma (PRP) injections, and a topical compound of finasteride and minoxidil, avoiding a hair transplant and oral finasteride. They experienced significant hair regrowth, particularly crediting the stem cell therapy for quick initial results.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Lavdik Hair Growth Serum?

      in Product 4 years ago
      A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.

    Related Research

    1 / 1 results