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GlossaryMyeloid-Derived Suppressor Cells

immune cells from bone marrow that suppress immune responses

Myeloid-Derived Suppressor Cells (MDSCs) are a type of immune cell that originates from bone marrow and has the ability to suppress the body's immune response. They play a significant role in cancer and other diseases by inhibiting the activity of T cells and natural killer cells, which can allow tumors to grow and spread more easily.

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research DC-HIL+ Myeloid-Derived Suppressor Cells Are Elevated in the Peripheral Blood and Lesional Skin of Cutaneous Lupus Patients

April 2018 in “Journal of Investigative Dermatology”

Cutaneous lupus patients have higher levels of certain immune cells in their blood and skin.

research Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway

10 citations, June 2016 in “PLOS ONE”

research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations, June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

research IL-17C: Checkpoint in Innate Skin Immunology

April 2018 in “Journal of Investigative Dermatology”

IL-17C is important in inflammatory skin diseases and could be a target for treatment.

research Metformin and Malignant Tumors: Not Over the Hill

14 citations, August 2021 in “Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy”

Metformin, a diabetes drug, may help prevent and treat various cancers, but more research is needed.

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