A Chronic Contact Eczema Impedes Migration of Antigen-Presenting Cells in Alopecia Areata

May 2006 in “ Journal of Investigative Dermatology ”

Pooja Gupta, Pia Freyschmidt‐Paul, Mario Vitacolonna, Sabine Kießling, Susanne Hummel, Dagmar Hildebrand, Rachid Marhaba, Margot Zöller

alopecia areata antigen-presenting cells chronic contact eczema squaric acid dibutyl ester T-cell chemokine monocytes dendritic cells lymph nodes leukocyte traffic hair follicle recovery AA APC SADBE

TLDR Chronic contact eczema may help hair regrowth in alopecia areata by reducing certain immune cell movement.

The study investigated the effects of chronic contact eczema on antigen-presenting cell (APC) migration in alopecia areata (AA) using a mouse model treated with squaric acid dibutyl ester (SADBE). It was found that while T-cell migration was unaffected, the treatment altered the chemokine environment, increasing monocytes in the skin and reducing dendritic cells in lymph nodes, which impeded APC migration from the skin to lymph nodes. This impaired migration potentially reduced T-cell activation, aiding hair follicle recovery. The study concluded that the therapeutic efficacy of SADBE in AA might be due to altered leukocyte traffic, specifically the reduced migration of APCs, with hair regrowth observed in 50-70% of human patients and 100% of mice.

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Expression of Vascular Endothelial Growth Factor, Apoptosis Inhibitors (Survivin and p16) and CCL27 in Alopecia Areata Before and After Diphencyprone Treatment: An Immunohistochemical Study

58 citations , May 2004 in “British Journal of Dermatology”

Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.

research Chronic Delayed-Type Hypersensitivity Reaction as a Means to Treat Alopecia Areata

20 citations , February 2004 in “Clinical & Experimental Immunology”

SADBE treatment led to complete hair regrowth in mice with alopecia areata by altering immune cell movement.

research Selective Expression of Chemokine Monokine Induced by Interferon-γ in Alopecia Areata

20 citations , September 2003 in “Journal of Investigative Dermatology”

research Alopecia Areata: Treatment of Today and Tomorrow

48 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Contact sensitizers like DCP and SADBE are the most effective treatments for alopecia areata.

research The Pathogenesis of Alopecia Areata in Rodent Models

23 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.

research Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata

77 citations , June 2002 in “Journal of Investigative Dermatology”

CD44 variant changes start alopecia areata, but don't maintain it.

research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

131 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.

Related Community Posts Join

6 / 1000+ results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 1 year ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community 25F and have been losing my hair for 10 years. Been to doctors, no issues with thyroid or hormones. No history of hair loss in my family. Wtf do I do?

in Question 12 upvotes 7 years ago

A 25-year-old woman has been losing hair for 10 years despite normal thyroid, hormone levels, and B12 supplementation. She has used Minoxidil with limited success and is considering hair transplants, Propecia, or shaving her head and wearing wigs.

community Alopecia Areata Question

in Treatment 2 upvotes 4 years ago

A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

community mbp alopecia areata or vitamin deficiency

in Chat 1 year ago

A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

community Olumiant alternative for Alopecia Areata?

in Treatment 1 upvotes 2 years ago

A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

Similar Research

5 / 1000+ results

research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations , June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

The Role of Lymphocytes in the Development and Treatment of Alopecia Areata

research The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results

59 citations , September 2008 in “Experimental dermatology”

Both mouse and rat models are effective for testing alopecia areata treatments.