TLDR Chronic contact eczema may help hair regrowth in alopecia areata by reducing certain immune cell movement.
The study investigated the effects of chronic contact eczema on antigen-presenting cell (APC) migration in alopecia areata (AA) using a mouse model treated with squaric acid dibutyl ester (SADBE). It was found that while T-cell migration was unaffected, the treatment altered the chemokine environment, increasing monocytes in the skin and reducing dendritic cells in lymph nodes, which impeded APC migration from the skin to lymph nodes. This impaired migration potentially reduced T-cell activation, aiding hair follicle recovery. The study concluded that the therapeutic efficacy of SADBE in AA might be due to altered leukocyte traffic, specifically the reduced migration of APCs, with hair regrowth observed in 50-70% of human patients and 100% of mice.
20 citations,
February 2004 in “Clinical & Experimental Immunology” SADBE treatment led to complete hair regrowth in mice with alopecia areata by altering immune cell movement.
48 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Contact sensitizers like DCP and SADBE are the most effective treatments for alopecia areata.
23 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.
77 citations,
June 2002 in “Journal of Investigative Dermatology” CD44 variant changes start alopecia areata, but don't maintain it.
131 citations,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.
45 citations,
June 2018 in “Frontiers in immunology” MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.
60 citations,
September 2015 in “Expert Review of Clinical Immunology” Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
191 citations,
May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
56 citations,
January 2021 in “Clinical and Experimental Medicine” The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.
59 citations,
September 2008 in “Experimental dermatology” Both mouse and rat models are effective for testing alopecia areata treatments.
