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Research

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research Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions

37 citations , February 2007 in “Experimental Dermatology”

This study found that PDCD4 protein expression is reduced in various skin cancers compared to normal skin, suggesting its potential role in preventing or treating certain skin cancers.

research Cell death as an architect of adult skin stem cell niches

April 2024 in “Cell death and differentiation”

This study discusses how different modes of regulated cell death in keratinocytes affect skin stem cell niches, and their role in skin inflammation, injury repair, and cancer, based on findings from human dermatological conditions and experimental mouse models.

Cell Death in the Skin: Mechanisms and Implications

research Cell death in the skin

120 citations , February 2009 in “Apoptosis”

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

research Cell death in skin function, inflammation, and disease

12 citations , August 2022 in “Biochemical Journal”

This review discusses the mechanisms of skin-associated cell death and their potential role in treating inflammatory skin diseases, but presents no new clinical findings.

research 332 OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

November 2022 in “Journal of Investigative Dermatology”

This study found that ILC1-like cells can induce alopecia areata in healthy human hair follicles, challenging the traditional belief that the disease is primarily driven by CD8+ T cells.

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Community Join

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community Mallia Aesthetics achieves key regulatory steps for novel sCD83-derived ingredient for hair growth

24 upvotes 1 year ago

Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.

community Opinions on best microneedling protocol? Some thoughts...

11 upvotes 3 years ago

Microneedling can enhance hair growth by improving minoxidil absorption and stimulating blood flow. Users discuss optimal needle depths, with some favoring shallow frequent needling for better absorption and others preferring deeper needling for stem cell activation.

community Microneedling depth. Does one length fit all areas of the scalp? Maybe not.

55 upvotes 4 years ago

Microneedling depth should be customized based on hair type and scalp area, with many users finding 0.5-0.6mm effective for miniaturized hairs to avoid damage. Users report varying pain levels and results, with some preferring shorter needle lengths and others using longer ones like 1.75mm for scalp health and density improvement.

community Microneedling and miniaturized hair follicles depth

in Microneedling 8 upvotes 1 year ago

Microneedling at depths greater than 0.6 mm may damage miniaturized hair follicles, with 0.5 mm showing better results for hair regrowth. Combining microneedling with minoxidil enhances absorption, but caution is advised to avoid damaging follicles.

community These yellow scales will be the death of me. Anyways I’m f’ed up

in Treatment 145 upvotes 8 months ago

Managing seborrheic dermatitis using ketoconazole shampoo, Nizoral, and oils like MCT and coconut oil. The user considers shaving their head and consulting a dermatologist.

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Learn

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learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

learn Stem Cell Factor

learn GHK-Cu

What is GHK-Cu and why is it said to be a "miracle" for hair? GHK-Cu is a copper peptide studied mainly for wound healing and skin repair; for hair loss the evidence stops at cell-culture and animal work, and no published human trial has tested it for androgenetic alopecia.

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Clinics

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